Exhibit 10.1

Equity Joint Venture Agreement

for the establishment of

AVAR (China) BioTherapeutics Ltd.

Table of Contents

THIS EQUITY JOINT VENTURE AGREEMENT (the “Agreement”) IS MADE AS OF THIS DAY OF OCTOBER 23, 2018 (the “Effective Date”), BY AND BETWEEN THE FOLLOWING PARTIES:

Avactis Biosciences, Inc., a corporation duly incorporated and existing under the laws of the State of Nevada and a wholly-owned subsidiary of Avalon GloboCare Corp. with its registration address at 4400 Route 9 South, Suite 3100, Freehold, New Jersey 07728, USA (hereinafter referred to as Party A), and

Arbele Limited, a limited liability company duly incorporated and existing under the laws of the Hong Kong Special Administrative Region of the People’s Republic of China (“PRC”) with its registration address at Unit 522, Biotech Center 2, 11 Science Park West Avenue, Shatin, N.T., Hong Kong, PRC (hereinafter referred to as Party B).

The abovementioned Party A and Party B are referred to as “the Party” individually and “the Parties” collectively hereafter.

After friendly negotiation conducted in accordance with the principals of equality and mutual benefit as outlined in the LETTER OF INTENT dated JULY 30, 2018 (Exhibit A), Party A and Party B, have agreed to establish a Sino-foreign equity joint venture — AVAR (China) BioTherapeutics Ltd. (hereinafter referred to as “Joint Venture”) in [city], [province] Province, PRC in accordance with the Law of the PRC on Sino-Foreign Equity Joint Ventures, the Joint Venture Law of the People’s Republic of China and other relevant laws and regulations, and the provision of this Joint Venture Contract.

Chapter I The Parties

Article 1 The Parties to this Contract are:

Chapter II           Establishment of Joint Venture

Article 2         The name of the Joint Venture shall be “[TBD]” in Chinese and “AVAR (China) BioTherapeutics Ltd.” in English. The legal address of the Joint Venture shall be [ TBD ].

Article 3        The Joint Venture shall be organized as a limited liability Joint Venture liable for all its debts only with its own property and assets. The liability of each Party shall be limited to the amount of the registered capital subscribed to by it. The rights and interests as well as risks shall be share by the Parties according to the respective percentages of their investments in the registered capital of the Joint Venture.

The Joint Venture shall be a legal person under the laws of the PRC, it shall observe the laws and regulations of the PRC and all of its activities shall be fully protected in accordance with the laws, regulations of the PRC. The Joint Venture shall independently undertake full civil responsibilities as an enterprise entity.

Chapter III Purpose and Business Scope

Article 4        The purpose and business scope of the Joint Venture is to research, develop, produce, sell, distribute and generally commercialize CAR-T/CAR-NK/TCR-T/universal cellular immunotherapy in the PRC as more fully described in Appendix A.

Article 5         Intentionally left blank.

Chapter IV Total Investment and Registered Capital

Article 6         Section 6.1 The total investment of the Joint Venture shall be USD $16.66 million .

Section 6.2 The registered capital of the Joint Venture shall be not less than 5,000,000 RMB.

Article 7        The registered capital of the Joint Venture shall not be reduced as long as the Joint Venture exists. However, if reduction is truly needed because of changes concerning total investment, production and operation size, and others, reduction may be made and must be approved by the approving authority.

Chapter V Contribution Proportion and the Timetable

Article 8         The contribution amount and proportion of the Parties are:

Article 9         The registered capital from Party A of not less than 5,000,000 RMB referenced in Section 6.2 shall be contributed by Party A as required by local regulations to provide initial working capital.

Article 10       Joint Venture is the legal owner of the assets contributed to the Joint Venture and enjoys the right to use the said capital contribution.

Article 11      Each Party may transfer all or any part of its interests in the Joint Venture, provided that it obtains the prior written consent of the other Party. When either of the Parties transfers all or any part interests in the Joint Venture, the other Party shall have a preemptive right to purchase the said interests under the same conditions. If either of the Parties transfers its equity of the Joint Venture to a third party, the transfer conditions shall be no more favorable than the conditions for transferring to the other shareholder.

Article 12       Intentionally Left Blank.

Chapter VI Responsibilities of the Parties

Article 13       Party A shall be responsible for the followings:

Article 14       Party B shall be responsible for the followings:

Chapter VII Confidentiality

Article 15     The Parties shall maintain any trade secret or other undisclosed information (referred to as “Information” hereafter) of the other shareholder or its affiliate companies they know during the performance of this Contract in strict confidence, except any of the following circumstances:

Chapter VIII Board of Directors

Article 16      The Board of Directors shall be the highest authority of the Joint Venture and shall decide all major issues of relating to the management of the business and affairs of the Joint Venture. The date on which the Joint Venture obtains its Business License shall be the date of establishment of the Board of Directors.

The Board of Directors shall consist of three (3) directors, of which two(2) directors shall be appointed by Party A who shall initially be David Jin, M.D., Ph.D and one other Director to be determined by Party A and agreed by Party B., one (1) director shall be appointed by Party B who shall initially be John Luk, Dr. Med.Sc., EMBA. The board of director shall have one (1) chairman, who shall be appointed by Party A who shall initially be Dr. Jin. The term of directors shall be three (3) years and may be renewed with the approval of the Party which appointed such Director. If any director is appointed and replaced, the Board of Director shall be notified in writing.

Article 17     The Chairman of the Board is the legal representative of the Joint Venture. In case that the Chairman is unable to perform his duties, the director appointed by Party B shall perform his duties temporarily.

Article 18      Any transfer of the equity in the Joint Venture shall require a resolution adopted by unanimous affirmative vote, either written or in person, of all members of the Board.

Article 19      The powers, the holding and calling procedure, the method for conducting business and the voting procedure of the board meeting shall be subject to the Joint Venture’s articles of association.

Chapter IX Supervisors

Article 20      The Joint Venture shall have two (2) Supervisors one of which will be appointed by Party A who shall initially be Dr. Jin and one of which will be appointed by Party B who shall initially be Dr. Luk. The term of supervisors shall be three (3) years and may be renewed with the approval of the Party which appointed such Supervisor.

Article 21       The supervisors shall have the following powers:

Chapter X Operation and Management

Article 22     The Joint Venture shall adopt a management organization consisting of one general manager, one deputy general manager, one chief financial officer and a number of senior officers. The general manger shall be nominated and appointed by the unanimous vote by the Board of Directors. The deputy general manager, chief financial officer and other senior officers shall be recommended by the general manager, shall be appointed by the Board of Directors, and shall be responsible for the general operation and management of the Joint Venture.

Article 23       If it is appointed by the Board of Directors, the chairman and directors may hold the office of general manger or other senior offices of the Joint Venture.

Article 24      The general manager shall report to the Board of Directors, shall execute resolutions made by the Board of Directors, shall exercise authorities and fulfill duties within the scope of authority granted by the Board of Directors, and shall organize and exercise the leadership in routine operation and business management of the Joint Venture. Personnel in charge of any subdivision of the Joint Venture shall fulfill their responsibility as assigned by the general manager and report their duty and performance to the general manager and the deputy general manager.

Article 25       The term of official authorities and other provisions for the general manager shall be prescribed by the articles of association. The general manager shall have the right to sit in on board meetings.

Article 26       In case the general manger or any one of senior offices commits an act of graft or serious dereliction of duty, they may be dismissed at any time upon the decision of the Board.

Article 27       The general manager shall submit accounting reports to the Parties according to the following schedule:

Chapter XI Labor Management

Article 28      The employment, recruitment, dismissal and resignation of the employees of the Joint Venture and their salary, welfare, labor insurance, labor protection, labor discipline, reward and penalty and other matters shall be handled in accordance with the regulations of labor and social security of the PRC. The plan shall be researched and developed by the Board of Directors, the labor contract shall be executed by the Joint Venture with employees, and labor contract system shall be applied to all employees. Once a labor contract is executed, it shall be filed with local labor management department.

Article 29       The Joint Venture shall pay social insurances including, but not limited to, pension insurance, unemployment insurance, medical insurance, childbirth insurance, and industrial injury insurance for employees in accordance with relevant exiting laws and regulations of China.

Article 30       The employment, salary, social insurance, welfare, travel expenses and others for senior officers of the Joint Venture shall be discussed and determined by the Board of Directors.

Chapter XII Insurance

Article 31       All insurances of the Joint Venture shall be bought from insurers in China; and the selection of insurer, risk coverage, insured value, and period of coverage shall be discussed and determined by the board meeting in accordance with provisions of the insurer selected.

Chapter XIII Finance, Accounting, Taxation, Foreign Exchange and Profit Distribution

Article 32       The financial, accounting system of the Joint Venture shall be developed in accordance with relevant laws and regulations of financial and accounting systems of China based on the Joint Venture’s situations and shall be filed with local financial and taxation departments. The Joint Venture shall pay taxes in accordance with relevant laws and relations of China and employees of the Joint Venture shall pay individual income tax according to the Individual Income Tax Law of the People’s Republic of China.

Article 33       Calendar year system shall be adopted as the fiscal year of the Joint Venture, i.e. a fiscal year is from January 1 to December 31 of a calendar year. Any self made voucher, report and account book shall be written in simplified Chinese.

Article 34       The Joint Venture shall submit accounting reports to the Parties, local taxation department and financial department at specified time.

Article 35       The Parties shall have the right to employ auditors or delegate authorized personnel at its own expense to check the account books, documents and any other material related to the assets and daily operation of the Joint Venture at any time. The Joint Venture shall provide convenience if the said checking is made.

Article 36      Chinese certified public accountants shall be employed to audit the financial accounting report of the Joint Venture, and the auditor result shall be reported to the board of director and the general manager.

Article 37       Any issue relating to foreign exchange of the Joint Venture shall be handled subject to the Regulations on the Foreign Exchange System of the People’s Republic of China and relevant management methods.

Article 38       After the income tax is paid according to the law, the profits of the Joint Venture shall be distributed based on following principles:

Article 39       It is not allowed to distribute profits before losses of the Joint Venture in previous years are not made up.

Article 40       Profits in previous years that are not distributed can be accounted into the profit of current fiscal year for distribution.

Chapter XIV Amendment, Addition, Change and Termination of Contract

Article 41     Any amendment or addition to this Contract and its Appendix can be effective only after the Parties reach unanimity, execute written Contract and submit the Contract to the original approving authority for approval.

Article 42      In case it fails to perform the obligations hereunder, in whole or in part, due to force majeure, the Contract may be amended, changed or terminated provided that there are definite references and evidences, and such amendment, change and termination are passed unanimously by the board of director and approved by the original approving authority.

Chapter XV Duration, Termination and Liquidation

Article 43      The duration of joint venture shall be 20 (twenty) years, which is counted from the date when its business license is issued. In case the Parties agree to extend the duration of joint venture, written application shall be submitted to the original approving authority six months before the expiration of the duration of joint venture, and the duration can only be extended after being approved; meanwhile change application shall be submitted to the industrial and commercial authority. The dissolution of the Joint Venture shall automatically cause the License Agreement to terminate.

Article 44       The Contract may be terminated in advance in case the Parties deem it will serve the best interests of both parties to do so.

Article 45       In case the Joint Venture terminates the Contract in advance, it shall be passed unanimously by the Board of Directors and submitted to the original approving authority for approval.

Article 46       The Joint Venture may be dissolved under any of the following circumstances:

If circumstances stated in item 2, 3, 5, 6 and 7 of the abovementioned article occur, the dissolution application shall be presented by the board of director and submitted to approving authority for approval; and if circumstance stated in item 4 occurs, application shall be presented by the party that performs the Contract and submitted to approving authority for approval.

Under the circumstance stated in item 4 of this article, the party that fails to perform the Shareholder Contract, the articles of association shall be liable to compensate the Joint Venture and the non-breaching party for losses incurred thereby; the non-breaching party shall have the right to apply to the approving authority for dissolving the Joint Venture according to the law.

Article 47      When the Joint Venture announces dissolution, liquidation shall be made. The Joint Venture shall set up a liquidation group in accordance with the Joint Venture Law to take charge of liquidation issues.

Article 48     The tasks for the liquidation group are to complete check the assets, claims and liabilities of the Joint Venture, compile balance sheet and assets list, put forward references for price fixing and calculation, develop liquidation plan, and execute the plan after it is passed by the board meeting.

Article 49       After the claims, liabilities of the Joint Venture are paid off by the liquidation group, the remaining assets shall be distributed to the Parties in proportion to the equity of Joint Venture held.

Article 50      On completion of the liquidation, the liquidation group shall submit a liquidation report to the original approving authority; and after it is passed by the board of director, formalities shall be gone through for nullifying registration in the industrial and commercial authority and business license shall be handed in, at the same time, an announcement shall be made to the public.

Article 51       Intentionally Left Blank.

Chapter XVI Liabilities for Breach of Contract

Article 52       In case this Contract can not be performed or can not be fully performed due to the breach of contract by one party, the breaching party shall take the liabilities for breach of contract; if both of the parties break the contract, each of the parties shall take relevant liabilities for breach of contract respectively based on practical situations.

Article 53      In case the Joint Venture fails to continue operation or achieve the business objective stated in the Contract due to either party does not perform obligations under the Contract and the articles of association, or violates provisions set forth in the Contract and the articles of associations, it shall be deemed that the breaching party terminates the Contract unilaterally.

Chapter XVII Force Majeure

Article 54      If any party fails to perform the Contract or fails to perform the Contract as per conditions agreed during joint venture due to direct impact produced by earthquake, typhoon, flood, fire, war or any other force majeure that is unforeseeable unavoidable and insurmountable, the party suffered force majeure shall notify the other party immediately and shall provide details of the force majeure as well as effective certification for reasons of failing to perform the Contract, in whole or in part, or requiring extension of performance period within fifteen (15) days, and the said certification shall be issued by a notary organ in the place where the force majeure occurs. Based on the degree of impact on the performance of Contract, whether the Contract is terminated, or the liability of performing a part of Contract is exempted, or the performance period is extended shall be determined by the Parties through consultation.

Chapter XVIII Applicable Law and Dispute Settlement

Article 55       The formation of this Contract, its validity, interpretation, execution and settlement of any dispute arising hereunder shall be governed by the laws of the PRC.

Article 56      Any dispute arising from the execution of this Contract shall be settled by the parties through friendly negotiation. In the event the Parties are unable to resolve the dispute through negotiation, the dispute shall be submitted to the China International Economic and Trade Arbitration Committee (CIETAC) located in Beijing for arbitration in accordance with valid arbitration rules of CIETAC. The arbitration award shall be final and binding on the Parties.

Article 57      In the course of arbitration, this Contract shall be continuously performed by both Parties except the part of this Contract which is under arbitration, the Parties shall exercise rights and perform obligations stipulated by this Contract at a time and in a manner prescribed hereby.

Chapter XIX Supplementary Provisions

Article 58       Chinese language shall be the uniform language used in office affairs of the Joint Venture.

Article 59     Any issue not duly covered in this Contract shall be executed in accordance with provisions set forth in the Law of the PRC on Sino-Foreign Equity Joint Ventures, the Regulations for the Implementation of the Law of the People’s Republic of China on Chinese-Foreign Equity Joint Ventures and other relevant laws and regulations; in addition, the parties may execute complementary Contract through friendly consultation as necessary and submit it to the approving authority for approval.

Article 60       The Appendix A and Exhibit A hereto are the indispensable part of this Contract and shall possess the same legal validity with this Contract.

Article 61       The Contract shall become effective upon the approval of the Ministry of Commerce of the PRC (or its authorized approving authority).

Article 62      In case of any notice delivered or sent by the Parties to the other by facsimile or e-mail involving the rights, obligations of the parties, a written letter shall be sent later for confirmation. The addresses listed in Article 1 hereof are the communication addresses of the Parties.

Article 63       This Contract is executed by the legal representatives (or duly authorized representatives) of the Parties on October [ ], 2018.

Article 64       This Contract is executed in ten counterparts, and each counterpart shall have the same legal validity. Each Party and the Joint Venture shall keep one original and the remaining shall be used for approval by, and registration and filing with relevant government departments and the industrial and commercial authority.

(This page is for the signature of the Shareholder Contract of AVAR (China) BioTherapeutics Ltd. only, with no text below)

Party A: Avactis Biosciences, Inc., a wholly-owned subsidiary of Avalon GloboCare Corp.

Party B: Arbele Limited

Appendix A

Joint Venture Purpose and Business Scope

[The Joint Venture is focused on the researching, developing, manufacturing, and commercializing cellular therapy, including (but not limited to) autologous CAR-T, CAR-NK, TCR-T, as well as allogeneic/universal cell-based immunotherapy for treating cancer patients in China with an initial focus on CD19 positive malignancies which shall include establishing a GMP-standard bio-manufacturing of proprietary CD19, CD22, and CD123 CAR-T biotherapeutics to support clinical studies of relapsed/refractory hematologic malignancies in China within two (2) years of the date hereof.

The Joint Venture shall be responsible for:

EXHIBIT A

LETTER OF INTENT